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This is very important, Last year Storm (Ravenmasque Golden Thunder) was given this- just a few weeks later became very ill with one of the diseases thought to be associated with this poison- just about a month after she was given ProHeart she had to be euthanised to stop her suffering..... I have added more links at the bottom of the page. Please do read up on any medications yuor vet wants to precsribe, and do not be afraid to tell them , not today I do not knwo about that medication.

here is one other information page http://concernedvet.netfirms.com/ which states one side effect is # Autoimmune hemolytic anemia (destruction of red blood cells) which is what Storm died of

http://www.fda.gov/bbs/topics/ANSWERS/2004/ANS01312 .html is where I found the following information!

FDA Talk Paper

T04-37 September 3, 2004

Media Inquiries: 301-827-6242 Consumer Inquiries: 888-INFO-FDA

Fort Dodge to Comply with FDA's Request to Recall ProHeart 6 Injectable Heartworm Product from the Market Due to Serious Health Concerns

Fort Dodge Animal Health, of Overland Park, Kansas, at FDA's request, has agreed to immediately cease production and recall its heartworm medication ProHeart®6 from the market until the FDA's concerns about adverse reaction reports associated with the product can be resolved. FDA is requesting that the firm continue to conduct research to determine the cause of related adverse reactions and develop a strategy to help prevent such problems in the future before the product is marketed again. The FDA will convene an independent scientific advisory committee to thoroughly evaluate all available data.

ProHeart®6 is an approved injectable sustained-release heartworm prevention product for dogs. Heartworm disease is a serious and potentially fatal condition of dogs, cats, and other species of mammals. The parasite that causes heartworm disease is transmitted through the bite of a mosquito.

FDA is also advising veterinarians to avoid administering this product to dogs until further notice. Pet owners should consult their veterinarians regarding their pet's health care needs.

Since the product was approved in June 2001, Fort Dodge Animal Health has cooperated with FDA to investigate numerous adverse event reports. As a result, Fort Dodge has voluntarily changed the label to include post approval safety information including rare reports of death and a caution to practitioners that dogs should have a negative test for heartworm before administration.

Despite these label changes, FDA is still receiving unexplained adverse event reports, some of them severe. FDA's concern is based on voluntary self-reporting to FDA by veterinarians and owners whose dogs have suffered adverse drug experiences (ADEs) to ProHeart®6 (which contains the drug moxidectin) as well as the mandatory reporting of adverse events by Fort Dodge Animal Health.

Fort Dodge Animal Health has agreed to recall any product that has already been distributed to veterinarians.

As of August 4, 2004, FDA's Center for Veterinary Medicine (CVM) had received 5,552 adverse event reports for ProHeart®6. The actual number of adverse events is likely even higher because studies show that only a fraction of actual ADEs are reported.

The Agency has observed an increase in the number of cases associated with liver and bleeding abnormalities followed in some cases by death.

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http://www.dogsadversereactions.com/moxidectin/ddoc03.html

http://www.proheart6.com/ (it has the letter on the site as well)

http://bewareofproheart6.freecyberzone.com/

http://www.nzymes.com/Articles/proheart_6_side_effects.htm